Harmonica position to isolate notes

Hi! My name is Mike, and I am currently taking the Beginner to Boss course. I am on Module 3 Single Notes, Lesson 8. I am learning so much from this course!

My topic concerns how I hold my harmonica in order to isolate a single note. I learned the technique of holding the harmonica at an angle, and I have been very happy so far with my results. It took some practice and patience, but I can keep up with Luke on the fast session of Low Rider now.

However, I stumbled upon a YouTube video Luke did on helping beginners learn how to isolate notes, and Luke tilts the harmonica up. When I learned to tilt, I was tilting the harmonica down, and I can isolate notes well. My concern is if my technique of tilting the harmonica down will inhibit my ability or growth at some point? Is there something that I may have trouble doing in the future, or is it OK to tilt the harmonica down?