Dai –Sorry to see this so late. If you’re going to be playing blues with the Tube5 here are my recs for getting a Chicago / “brown sound”. So, about replacing tubes (6V6 and 12ax7) and speaker (Weber ceramic),
I’d recommend replacing the 6V6 with a 5881 (warmer, more headroom, cleaner top end) and the 12ax7 with a 12AY7 (45% gain – richer, warmer, possibly less volume) Alternatively, a 12AT7 (60% gain). Try both. The AX is fine for guitar, or loud, thin harp.
Go with NOS (New Old Stock) tubes. I see Brent Jesse Audio has just retired after 30 years, but they say to keep an eye on their website to see who bought their stock. Their website (still up and running) is a great source of tube information. Fun, educational reading.
Speaker? I don’t like the Weber Signature series. Too thin. I’d go with a Weber Vintage series 8A125-O with dust cap. For the instant broken in, aged speaker sound, just put some fabric softener on a rag and lightly rub the cone (dampen, not saturated). Wait, second time. Wait, third time.
Weber 8A125-O. A vintage sound. Recommended to replace Oxford 8EV, vintage Chicago Jensen P8R, P8Q, C8R, and other 8″ applications. 8″, 11oz AlNiCo plug magnet, 20 watts, 1-1/4″ voice coil, smooth cone. Warm, crunchy, early breakup, compressed/fattened at high volume.
The speaker thing is always hard because everyone has a different sound in their head, Most online demos are with guitars. If there’s more than one speaker, you don’t know how it will sound until after you buy and install. Good luck.